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A new study from researchers at The University of Texas MD Anderson Cancer Center has uncovered how one of the most common genetic alterations in glioma rewires the cancer cell genome to fuel tumor progression, suggesting a potential new therapeutic strategy for patients with ATR

Hiroshima University researchers have demonstrated a proof of concept for the mass production of genome-edited T cells that can be used to treat malignant tumors, using a genetic engineering technique called Platinum TALEN.

Biohub researchers have performed what they believe is the first genome-wide CRISPR study of primary human adult skin cells, then used an AI model to mine the results for overlooked drug targets for psoriasis. They found an unlikely candidate: the receptor for oxytocin, a hormone

Rat disease models have played an integral role in scientific discovery and cancer research, including Nobel Prize–winning work from Charles Huggins on hormone therapy for prostate cancer in 1966. However, technical challenges in genetic engineering of rat models have limited the

A form of glioma, a type of brain cancer, tends to progress toward greater malignancy due to an increasing tendency of glioma cells to transform into immature, stem cell-like states, according to a study led by investigators at Weill Cornell Medicine, the New York Genome Center,

A hidden population of South African leopards has revealed a remarkable evolutionary story. Researchers analyzing entire leopard genomes discovered that the Cape Floristic Region’s leopards are not only much smaller than most African leopards, but also genetically distinct after

Genome editing lets scientists rewrite DNA, the instruction manual inside every living cell, with a precision that was unthinkable a generation ago. Technologies such as CRISPR have made this almost routine, and its uses now reach far beyond medicine, from engineering hardier cro

For more than three decades, researchers studying genomes have relied on foundational resources such as Repbase and, more recently, Dfam to identify and classify transposable elements—the mobile DNA sequences that shape genome structure, evolution and function. Now, Dfam and Repb

Every time a cell copies its DNA, parts of the genome are exposed and vulnerable to damage or errors. Molecular biologist Simon Boulton is interested in how cells spot and repair damage to their DNA, and what happens if this process fails or if key genes are mutated.

Researchers have spent decades—and billions of dollars—sequencing animal and crop genomes, but fungi have historically been the forgotten middle child of genomics, only noticed when they're ruining bread or colonizing toes.

In a study published in Science Translational Medicine, a team of researchers led by Dr. Wang Yu from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences developed PRINCE and Little Prince, dual small-molecule-controlled genome editing systems that a