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Over the past few decades, scientists have become increasingly interested in developing materials that do not simply withstand mechanical forces but instead respond to them in useful, detectable ways. For example, it is now possible to engineer materials that signal when they are

Rotaxanes are dumbbell-shaped mechanically interlocked molecules in which one or more ring-shaped molecules are threaded through a linear segment, known as the axle. To keep the ring from sliding off, two bulky groups, sometimes called stoppers, are added to the ends of the axle.

IMDEA Materials Institute has developed mechanically tunable hydrogel membranes that closely mimic the mechanical environment of human skin while remaining highly biocompatible, representing an improved platform for skin tissue engineering and regenerative medicine.