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Researchers have developed a new computational approach that enables more accurate selection of genes that characterize different cellular states from mRNA-seq data, offering a more interpretable way to analyze complex biological data. The study, published in Frontiers in Immunol

The nucleolus is a liquid-like cellular organelle where protein factories called ribosomes are assembled. Researchers knew of three distinct compartments within the nucleolus, but how these compartments function to drive ribosome assembly was unclear. A study from St. Jude Childr

A night without sleep produced increased markers of connections between brain cells, showing that sleep in humans may be important for restoring cellular balance in the brain, according to a study published in PLOS Biology by David Elmenhorst from the Forschungszentrum Jülich Ins

Aging affects every organ in the body, yet we still know little about how the ovary changes over time. In a new study published in Nature Aging, Yale researchers created one of the most detailed maps of the aging ovary to date, examining how its cellular organization changes acro

In a recent study published in Nature Communications, researchers at Karolinska Institutet report that the molecular machinery responsible for cellular energy conversion is more interconnected than previously understood, shedding light on how mitochondria adapt under stress.

Researchers at Hospital for Special Surgery (HSS) have uncovered a critical link between the immune system in early life and its function in adulthood. The study, published in Science Immunology, identifies a new role for specialized skin immune cells, called Langerhans cells, in

Researchers at the University of Colorado Anschutz have found that healthy yet sedentary individuals show a significant, coordinated drop in muscle mitochondrial function that may precede the development of major diseases like cancer, diabetes, and Alzheimer's. The work is publis

Autophagy is the process by which cells remove damaged proteins, recycle worn-out organelles (e.g., mitochondria), clear cellular waste and provide nutrients during stress. Autophagy is essential for muscles because they are constantly under mechanical stress. If autophagy is too

The human brain contains billions of neurons, specialized nerve cells that communicate with each other via electrical and chemical signals. Every neuron is made up of its body (i.e., soma), where most cellular processes occur; a long projection called an axon that sends signals t

Scientists at UT Southwestern Medical Center have discovered that gut bacteria help regulate the development of the body's immune system by directing the movement of vitamin A through a previously unrecognized cellular network. The preclinical findings, published in Cell Host & M

For most women past puberty, the uterine lining (endometrium) sheds from the body roughly every month if there is no fertilized egg present. Then, the uterus rebuilds itself to prepare for a potential pregnancy. While this process—the menstrual cycle—is widely known, how it works

Australian researchers have discovered that even a modest reduction in the protein BECLIN1 leads to a significant increase in gut inflammation, which can lead to further disease and complications over time.