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Researchers have discovered that a microscopic skeleton inside neurons does much more than hold cells together. It acts as a gatekeeper that controls what brain cells absorb and when they absorb it. When this protective structure weakens, neurons rapidly take in harmful proteins

A new study from the Knight Initiative for Brain Resilience researchers may help explain an enduring mystery about amyotrophic lateral sclerosis (ALS): why the disease kills off some of the brain and spinal cord's movement-controlling neurons while others show greater resilience.

Studies of genetics conducted in yeast cells, human neurons, mice or other model systems often reveal networks of genes that could contribute to complex diseases, such as breast cancer, type 2 diabetes and Parkinson's disease. But those findings don't always translate to human bi

Alzheimer's disease is driven by a buildup of a toxic protein called Tau that kills neurons. As toxic Tau spreads to new regions of the brain, symptoms worsen and ultimately become fatal.

The environment experienced by young zebrafish influences both the shape and electrical activity of the neurons in the eye, which affects subsequent behavior.

Over the past decade, researchers at WashU Medicine have established that a molecule called SARM1 is a central trigger in the loss of axons, the vital wiring of the nervous system. Axon loss is characteristic of many neurodegenerative diseases, such as amyotrophic lateral scleros

A research team led by Prof. Hyosang Lee of the Department of Brain Sciences at DGIST has identified TWIK-1, a type of potassium channel expressed in the spinal cord and peripheral sensory neurons of the somatosensory system, as a key molecular regulator of touch sensation and ch

A molecule linked to chronic inflammation disrupts the brain's ability to create new neurons, uncovering a pathway with therapeutic potential for neurodegenerative diseases and neurological conditions. The King's College London study, published in Nature Communications, offers in

The human brain contains billions of neurons, specialized nerve cells that communicate with each other via electrical and chemical signals. Every neuron is made up of its body (i.e., soma), where most cellular processes occur; a long projection called an axon that sends signals t

If you are crossing an unfamiliar room in the dark, you may grope around a bit to get a sense of your space. But for many animals, feeling out a space comes more naturally. A mouse, for instance, can efficiently navigate in the dark just by grazing its whiskers against walls and

It's a fact of life that the electrical activity of neurons will vary during the same task, even when the ultimate outcome is the same. A new study shows that a lot of ongoing fluctuations in the brain's activity can be explained by the influence local electric fields exert on th

Accumulation of DNA damage in the brain's neurons may contribute to the development of Alzheimer's disease. New research in FEBS Open Bio demonstrates the therapeutic potential of a drug that targets this process.