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Forcing cancer cells to die can alert the immune system to enhance anti-tumor attack
Unlike accidental cell death, some cells can actively decide to die through a controlled process. This is called programmed cell death and can occur in different forms, including apoptosis and necroptosis. Cells use this process when they are damaged, stressed, becoming cancerous
Platinum TALEN enables mass production of engineered cancer-fighting T cells
Hiroshima University researchers have demonstrated a proof of concept for the mass production of genome-edited T cells that can be used to treat malignant tumors, using a genetic engineering technique called Platinum TALEN.
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Emerging evidence links tire pollution to Alzheimer's risk
A chemical called 6PPD-quinone (6PPD-Q), which forms when shaved-off tire particles come into contact with ozone, might interfere with the inner workings of brain cells, leading to Alzheimer's disease. Zhang and Zhang's new paper in the journal Open Medicine, "6PPD‑Quinone Exposu
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Hormone differences could pave way for endometriosis blood test
People with endometriosis have a distinct pattern of hormones that could be identified by a blood test, with the potential to revolutionize diagnosis of the condition, research suggests. Scientists have found that those with endometriosis have differences in a previously overlook
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Neuroscientists observe electrical signals in the soma and dendrites of living mice
The human brain contains billions of neurons, specialized nerve cells that communicate with each other via electrical and chemical signals. Every neuron is made up of its body (i.e., soma), where most cellular processes occur; a long projection called an axon that sends signals t
A new soccer concussion protocol could make one of the game's hardest calls much faster
The World Cup has the globe glued to TV screens, watching 22 soccer players work their magic on the field. Every so often, one of them takes a hard hit to the head from the ball or another player's head, and they often continue playing because there is no onsite way to check for
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Get better sleep with ultrasound patch that boosts REM rest
A University of Texas at Austin-led team of researchers has developed a noninvasive patch that boosts REM sleep in real-world trials without surgery or medication. The technology, called NEUSLeeP, is a soft, wearable device that uses gentle ultrasound waves and electrodes to stim
Gene clues reveal why some rare leukemia patients resist tagraxofusp therapy
Researchers at The University of Texas MD Anderson Cancer Center have identified why some patients with a rare type of leukemia, called blastic plasmacytoid dendritic cell neoplasm (BPDCN), eventually develop resistance to tagraxofusp, the first Food and Drug Administration-appro
Five-agent AI team could speed clinical trial design using real-world patient records
Five-agent AI team could speed clinical trial design using real-world patient records
An artificial intelligence system that operates like a collaborative team of medical experts could accelerate clinical trial design, one of the most difficult steps in drug development, according to a new study by Weill Cornell Medicine investigators. The findings, published in N
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Electric fields could organize neural activity trial by trial during memory tasks
It's a fact of life that the electrical activity of neurons will vary during the same task, even when the ultimate outcome is the same. A new study shows that a lot of ongoing fluctuations in the brain's activity can be explained by the influence local electric fields exert on th
Genetic insights into a fluid-related brain condition in newborns
Early detection and treatment of congenital cerebral ventriculomegaly (CCV)—when a fetus's fluid-filled brain ventricles swell due to a condition called hydrocephalus—can help clinicians prevent developmental or neurological disabilities in affected infants. New research led by i
AI-guided CRISPR uncovers oxytocin receptor as unexpected psoriasis drug target
Biohub researchers have performed what they believe is the first genome-wide CRISPR study of primary human adult skin cells, then used an AI model to mine the results for overlooked drug targets for psoriasis. They found an unlikely candidate: the receptor for oxytocin, a hormone