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Four-decade mystery solved as PKCβ structure reveals new drug target

After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structure of protein kinase C beta (PKCβ), a key protein linked to cancer and neurological diseases. The findings, published in Nature Communications, provide the first detailed view of how

Admin Recifes 15/07/2026 2

Artificial DNA tiles could deliver drugs and monitor neurons non-disruptively

Living cells constantly exchange ions (i.e., charged particles) via the thin barrier that surrounds their interior, known as the outer membrane. Neuroscientists and medical researchers have long been trying to devise effective methods to measure this exchange of ions, which is kn

Admin Recifes 15/07/2026 1

Mathematical modeling helps advance use of magnetic particles in targeted drug-delivery sy

A Florida State University computational scientist is paving the way for future medical breakthroughs by developing mathematical models and simulations to predict the behavior of a unique drug-delivery method, which aims to deploy treatments directly to targeted sites in the body

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Researchers develop a new prodrug and localized drug delivery platform for selective treat

A new collaborative study reports the discovery and application of a novel therapeutic strategy to selectively target EGFR and other kinases with controlled release in tumor microenvironments to improve therapeutic efficacy, with promising results. The research is published in Bi

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FDA-approved drug may finally help immunotherapy defeat rare liver cancer

Researchers found that a rare liver cancer evades immunotherapy by luring immune T cells away from the tumor and trapping them in nearby fibrous tissue. An FDA-approved drug called AMD3100 freed those T cells to attack the cancer, significantly improving the effectiveness of immu

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Scientists measure hidden quantum forces that could power a new generation of pharmaceutic

It's one thing to design a pharmaceutical drug. It's another to know if and why it actually works; not on paper or in a computer model, but inside the chaotic world of living systems, where proteins twist into shape, atoms constantly pull and push each other apart, and molecular

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Nanopore technology identifies proteins molecule by molecule

Proteins are responsible for most functions in the human body. However, their analysis, which is essential for understanding diseases, developing drugs and discovering new biomarkers, remains highly complex. Using a technology called "nanopore detection," a team at the University

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Structural blueprint for RNA therapeutics reveals why some siRNA molecules work better tha

RNA interference is a natural mechanism for living cells to control whether specific genes are being used. Crowned with the 2006 Nobel Prize in Physiology or Medicine, the discovery of RNA interference has since been harnessed by scientists to create a powerful and growing class

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Table sugar could hold a cheaper, quicker key to making vital drugs

Pioneering research has developed a new way of creating carbohydrate-based medicines that could ultimately replace costly drugs for common health conditions, using two cheap basic ingredients—table sugar and vinegar.

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‘Beautiful blobs’: synthetic life a step closer as scientists make cells using lab-made DN

Tiny, quivering spheres designed to feed and multiply raise prospect of artificial organisms to make drugs, food and fuelResearchers claim they are closer to creating life from scratch after building tiny, quivering blobs that use lab-made DNA to feed, grow and multiply in a dish

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Nanozymes map nanoparticle routes inside live cells without genetic engineering

Nanoparticles are widely used in medicine to deliver drugs, genes or imaging agents to specific parts of the body. Once a nanoparticle reaches a cell, however, many things can happen—it can reach its target, be degraded, interact with proteins that help transport it, or interact

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Small-molecule switches put therapeutic CRISPR editing under on-demand control in living t

In a study published in Science Translational Medicine, a team of researchers led by Dr. Wang Yu from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences developed PRINCE and Little Prince, dual small-molecule-controlled genome editing systems that a

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