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Molecular machinery in cardiac mitochondria reacts to metabolic stress in unexpected way
In a recent study published in Nature Communications, researchers at Karolinska Institutet report that the molecular machinery responsible for cellular energy conversion is more interconnected than previously understood, shedding light on how mitochondria adapt under stress.
First potential probiotic treatment for lupus identified by researchers
First potential probiotic treatment for lupus identified by researchers
Scientists at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, have found a link between a bacterium in the gut microbiome (ecosystem) and lupus that could lead to more effective treatment of the disease, described in a study published
BCG vaccine may rewire brain immunity, shift Alzheimer's markers over 12 months
New research led by Mass General Brigham investigators suggests that the Bacillus Calmette-Guérin (BCG) vaccine—which is delivered through the skin to prevent tuberculosis—may remodel the human brain's immune environment, offering a potential biological explanation for previously
Two prostate cancer mutations reveal opposite responses to ferroptosis therapy
A new study by researchers at The University of Texas MD Anderson Cancer Center has identified genetic factors that determine whether prostate cancers are susceptible to a type of cell death known as ferroptosis. These findings, published in Nature Communications, could help guid
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Invisible threads: How our environment quietly shapes disease
From the air we breathe to the food we eat, we are constantly exposed to thousands of chemicals—yet how these exposures affect our health has remained surprisingly difficult to understand. A new study led by researchers at the CeMM Research Center for Molecular Medicine of the Au
Repurposed cancer drug rapidly eased rare autoimmune neuropathy in two patients
An interdisciplinary team at Jena University Hospital achieved a surprisingly rapid and significant improvement in two patients with an autoimmune peripheral nervous system disorder. The team administered teclistamab, a drug originally developed for multiple myeloma, and reported
Fibronectin pathway may drive Marfan aortic damage, opening new drug targets
A new study published in Nature Communications identifies a molecular signaling pathway that contributes to the development of life-threatening aortic aneurysms and dissections in Marfan syndrome, a genetic disorder affecting connective tissue. The findings provide new insight in
TNF-alpha blocks new neurons in hippocampus, reveals inflammation pathway
A molecule linked to chronic inflammation disrupts the brain's ability to create new neurons, uncovering a pathway with therapeutic potential for neurodegenerative diseases and neurological conditions. The King's College London study, published in Nature Communications, offers in
Five-agent AI team could speed clinical trial design using real-world patient records
Five-agent AI team could speed clinical trial design using real-world patient records
An artificial intelligence system that operates like a collaborative team of medical experts could accelerate clinical trial design, one of the most difficult steps in drug development, according to a new study by Weill Cornell Medicine investigators. The findings, published in N
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Team discovers metabolic pathway in cell nucleus that helps cancer progress
A team at Roswell Park Comprehensive Cancer Center has identified a novel metabolic pathway that plays a key role in enabling cancer to progress through gene activation. In a new study published in the journal Nature Communications, the researchers show that shutting down the pat
How studying oral inflammatory diseases can help researchers understand other human diseas
A team of researchers from VCU Massey Comprehensive Cancer Center, the VCU School of Dentistry and the University of Pennsylvania recently published a study in Nature Communications examining why some oral inflammatory diseases progress much more rapidly than others.
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Signaling pathway may help predict immunotherapy response in glioblastoma
Northwestern Medicine scientists have uncovered a biological mechanism that helps explain why most patients with glioblastoma fail to respond to immunotherapy, according to their study published in Nature Communications.