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Although opioids remain indispensable for pain relief in patients with advanced cancer, their use frequently results in OIC, which can substantially reduce quality of life and, in some cases, compromise the continuation of optimal pain management. Naldemedine, a peripherally acti

Researchers found that 58% of total dementia-related costs are linked to unpaid care provided by family members, friends and other informal caregivers, highlighting the substantial burden of dementia beyond health care systems alone. Notably, unpaid informal care (€128 billion an

An analysis of the brain of a deceased Alzheimer's disease (AD) clinical trial participant found that regions where an anti-amyloid therapy successfully cleared amyloid plaques showed little to no evidence of tau tangles, a hallmark of AD closely linked to neurodegeneration and c

Ultrafine particles (UFPs) –smaller than 100 nanometres and invisible to the naked eye—contribute substantially to illness and mortality worldwide. That is the finding of an international study led by researchers at the Max Planck Institute for Chemistry in Mainz and The Cyprus I

British carrier says it hopes to receive ‘more attractive proposal that better reflects’ its valueBusiness live – latest updatesEasyJet has opened talks with Castlelake, despite rejecting a fourth takeover offer worth £4.9bn from the US investment firm, with the airline saying it

President’s crypto ventures have eclipsed in revenue much of his property portfolio that took decades to accumulateDonald Trump raked in more than $1bn from his crypto businesses last year, a federal filing released on Tuesday shows, giving a substantial boost to his annual incom

Almost all major Asian stock markets fall, with Samsung Electronics shares sliding for a second dayAssociated British Foods, the owner of Twinings, Kingsmill and Primark, is to rename its baker arm Hovis Bakeries after completing the takeover of rival baker Hovis.The company appe

Susan Randall on Stephen Timms’ Pip review and those with longstanding mental illness and Ruth Lister on why social security spending shouldn’t be called ‘welfare’. Plus letters from Luke Howard and Katie MeddWith reference to your editorial (The Guardian view on disability benef

Relentless rains are threatening a lake in Kenya’s Great Rift Valley that has become a key hub in the global flower trade.

Teenage Engineering has already issued multiple substantial updates for its surprisingly capable $329 EP-133 KO II sampler. Its latest is one of the biggest yet. OS 2.5 adds audio over USB, selectable sample rates for lo-fi fun, sample reverse, an arpeggiator, equal-length autoch

Published in Nature Climate Change, new research from the University of Wisconsin–Madison finds that reaching net-zero emissions by midcentury would substantially improve public health in the United States. However, climate strategies that heavily depend on carbon dioxide removal

Researchers from the Coller School of Management at Tel Aviv University examined the Ministry of Economy's flagship "Israel's Basket" initiative and found that although it substantially reduced the prices of the 100 products included in the program, these reductions were accompan