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African genetic data could change how essential medicines are prescribed
The dosage information for drugs used in HIV treatment, malaria, cancer care, pain management and transplantation is largely based on data from European patients and fails to include vital information about how essential drugs work in diverse African populations. A Wits-led polic
Elucidating a decades-old mystery of blood clotting
Why is it rare for dangerous blood clots to form in our blood? What happens if this safety mechanism fails? An international team of researchers involving the University of Greifswald has taken a major step toward finding the answer to this central medical question. The results w
GLP-1 drugs outperform SGLT-2 drugs for patients with Afib and type 2 diabetes
Individuals with atrial fibrillation (Afib), or irregular heart rhythm, are at increased risk of stroke, chronic kidney disease and heart failure. These risks are significantly exacerbated if a type 2 diabetes diagnosis is added to the mix, says Md Mohaimenul Islam, Ph.D., resear
Common mucus-clearing treatments don't help ICU patients breathe easier and may cause harm
Common mucus-clearing treatments don't help ICU patients breathe easier and may cause harm
For patients struggling to breathe because of acute respiratory failure, clearing mucus from the airways is a routine part of treatment. Mucoactive agents are widely used for this purpose. But after years of clinical use, one question remains: Do mucoactive agents actually help?
'Polypill' for heart failure cuts hospitalizations and ER visits by 60% in trial
A "polypill" combining three medications recommended to treat heart failure into a single daily dose proved far more effective for patients than taking the drugs separately, a randomized clinical trial led by UT Southwestern Medical Center researchers showed. The findings, publis
Chromatin hubs help decide whether T cells fight chronic threats or fail
Chronic and viral infections can literally exhaust certain key cells in the immune system from a constant barrage of attacks. But a new pair of papers by scientists at the Hackensack Meridian Center for Discovery and Innovation (CDI) points to a way to understand how this exhaust
Kidney disease profile shifts: Diabetes-linked CKD rises as overall US rate stalls
Chronic kidney disease (CKD) is common, largely silent and serious. Most people who have the condition do not realize they have it, while it sharply raises the risk of heart attacks, strokes, kidney failure and early death. Over the past decade, the share of American adults livin
One-size-fits-all fetal growth charts often fail to spot at-risk babies, large study finds
One-size-fits-all fetal growth charts used in the NHS to monitor babies' growth before birth often misclassify babies as being either too small or too large, which can lead to missed cases at risk of stillbirth or unnecessary interventions, finds a study of more than 3 million NH
Womb fluid infusions help fetuses with kidney failure survive after birth
Women diagnosed early in pregnancy with a fetus lacking adequate kidney function to make the urine that serves as vital amniotic fluid have long faced virtually no chance of the fetus's survival after birth.
Foto: Veronica / Pexels
Artemisinin resistance is rising in East Africa—leaving anti-malarials at risk of failure
Resistance to the main drug in front-line malaria treatments is becoming more widespread across East Africa, according to new research by Imperial College London. The study, published in The Lancet Infectious Diseases, maps the rise in artemisinin resistance in the region and sug
Foto: Anna Tarazevich / Pexels
Signaling pathway may help predict immunotherapy response in glioblastoma
Northwestern Medicine scientists have uncovered a biological mechanism that helps explain why most patients with glioblastoma fail to respond to immunotherapy, according to their study published in Nature Communications.
Rapid magnetic brain stimulation eases depression within days, but benefits fade within we
Despite decades of advances in mental health care, depression remains one of the world's most disabling conditions. Many people with major depressive disorder (MDD) fail to find lasting relief from antidepressants or psychological therapies. Studies indicate that the global burde