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166 notícias encontradas para "models"
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Emerging mRNA vaccine strategies target cancer and pathogenic viruses in potent new ways
The technology that gave the world mRNA COVID vaccines is being tested in a variety of new ways, and emerging research reveals that a crucial T-cell population can be reprogrammed in animal models by reimagining the science that was introduced to the public at the height of the p
Could one shot replace weekly GLP-1 drugs? DNA approach shows months-long effects in mice
Could one shot replace weekly GLP-1 drugs? DNA approach shows months-long effects in mice
Scientists at The Wistar Institute have shown that a single injection of a small, circular piece of genetic instruction can produce weight loss and blood glucose control in murine models that lasts up to 10 times as long as incretin-mimicking drugs like Ozempic and Wegovy. If sho
Mouse model supports long-held belief that viruses can trigger Parkinson's disease
Scientists usually use animal models when studying Parkinson's disease because these models mimic the disease well. They are limited, however, because they require either gene modifications or the injection of toxicants, which may not accurately represent how the disease occurs i
Human red blood cells form without central 'hub' seen in mouse models, upending understand
Northwestern Medicine scientists have discovered that one of the body's most fundamental biological processes—how red blood cells are made—works differently in humans than previously thought, according to a new study published in Nature Genetics. The findings overturn decades of
Biomarker-matched drug combos shrink treatment-resistant melanoma in preclinical models
A new study led by researchers at The University of Texas MD Anderson Cancer Center has identified a way to tailor drug combinations based on specific tumor biology to improve outcomes for treatment-resistant advanced melanoma.
Drug candidate treats severe fatty liver disease by protecting the gut in animal models
Researchers discovered that a potential drug developed at Michigan Medicine treats severe fatty liver disease by improving gut health, according to a study published in The Journal of Clinical Investigation.
New approach could expand CAR T therapy from blood cancers to solid tumors
New approach could expand CAR T therapy from blood cancers to solid tumors
Researchers at the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute report that combining CAR T cell immunotherapy with a targeted radiopharmaceutical significantly improved tumor regression in preclinical models of neuroblastoma, a rare and
Alcohol drives opposite brain circuit changes in amyloid and tau Alzheimer's models
Alcohol use has been associated with an increased risk of cognitive decline and dementia. But new research from Texas A&M University's Naresh K. Vashisht College of Medicine at Texas A&M Health suggests the relationship between alcohol and Alzheimer's disease is more complicated
Foto: Roman Biernacki / Pexels
Gut bacteria linked to malnutrition may pass to younger generations
A study led by researchers at Washington University School of Medicine in St. Louis suggests that an intestinal disorder linked to malnutrition and stunted growth may be transmitted from one generation to the next via the small intestinal microbiome. Analyzing mouse models of the
Medical AI may look less biased on paper but not in practice, new study finds
Large language models (LLMs) are only as good as the data they learn from. If their training data contains social biases, the models may unintentionally repeat those biases in their responses. As their use increases with the rise of generative AI, it has become evident that they
Genome editing in rats enables more accurate estrogen receptor-positive breast cancer mode
Rat disease models have played an integral role in scientific discovery and cancer research, including Nobel Prize–winning work from Charles Huggins on hormone therapy for prostate cancer in 1966. However, technical challenges in genetic engineering of rat models have limited the
The same sounds are mapped similarly in the human and mouse brain, study finds
While exploring the world around them, both humans and other animals continuously interpret information they pick up with their sight, hearing, touch and other senses. Neuroscience research suggests that the brain does not individually process every single sensory experience, but