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Interim clinical findings from the first Phase I/IIa trial using autologous-induced pluripotent stem cell (iPSC)-derived dopamine neuron precursor cells, along with the novel quality-control tools developed to manufacture these individualized therapies, have been presented by Jea

An update on the first clinical trial evaluating a pluripotent stem cell-derived neural stem cell therapy for Huntington's disease was presented at the ISSCR 2026 Annual Meeting. The Phase Ib/IIa REGEN4HD study represents a significant translational milestone following years of p

The U.S. Food and Drug Administration has issued a supplemental approval for Casgevy (exagamglogene autotemcel) for patients ages 2 and older with either sickle cell disease (SCD) with recurrent vaso-occlusive crises (VOCs) or transfusion-dependent β thalassemia (TDT). Supplement

A new therapy helps achieve a healthier BMI in people whose weight has become dysregulated following treatment for a brain tumor, a clinical trial has found. The results of the trial have been published in the New England Journal of Medicine. The new drug, setmelanotide, offers h

A small pilot study from the Center for Psychedelic Research at Imperial College London indicates that psilocybin—the active ingredient in psychedelic "magic mushrooms"—may have potential as a treatment for anorexia nervosa when combined with therapy. Anorexia nervosa is a seriou

Obesity and dietitian societies have joined forces to issue a new consensus statement on recommendations surrounding the use of obesity drugs for weight loss treatment. The statement, which is published in The Lancet Diabetes & Endocrinology, is led by Dr. Laurence Dobbie of the

Rat disease models have played an integral role in scientific discovery and cancer research, including Nobel Prize–winning work from Charles Huggins on hormone therapy for prostate cancer in 1966. However, technical challenges in genetic engineering of rat models have limited the

Epilepsy affects more than 50 million people worldwide, making it one of the most common neurological disorders. Although medication helps many patients achieve seizure control, approximately one-third continue to experience seizures despite treatment. Seizures often arise when t

New research presented at the International Society for Stem Cell Research (ISSCR) 2026 Annual Meeting highlights a significant step toward developing a stem cell-based treatment for chronic spinal cord injury (SCI), a condition for which no effective restorative therapy currentl

New research presented at the International Society for Stem Cell Research (ISSCR) 2026 Annual Meeting explores an approach that could expand the potential of cell replacement therapy for type 1 diabetes by evaluating whether immune-engineered, allogeneic insulin-producing cells

A healthy bone marrow (BM) produces nearly all types of cells in our blood. Many blood disorders occur when hematopoietic stem cells (HSCs) in the BM malfunction. Treatment with radiation or chemotherapy for many blood disorders and cancers can, as a side effect, deplete not only

A University of East Anglia project to help caregivers looking after people with dementia has been hailed a success. Researchers created a digital therapy platform for use on mobile devices or computers and tested it with almost 500 volunteers.