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243 notícias encontradas para "mole"
Foto: Jakub Zerdzicki / Pexels
Mapping the hidden rules of a key immune sensor
The immune system depends on molecular alarms that detect danger inside cells. One of these alarms is STING, short for "stimulator of interferon genes." STING helps cells respond to infections, damaged DNA and cancer. When it activates at the right time, it helps protect the body
Foto: Darina Belonogova / Pexels
Eliminating cancer cells that survive KRAS inhibition: A potential way to prevent relapse
Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory systems are disrupted, cells can acquire the ability to grow uncontrollably and become cancerous. One of the most important cancer-related signaling molecul
Foto: Google DeepMind / Pexels
Vulnerable ALS neurons reveal molecular warning signs before cell death begins
A new study from the Knight Initiative for Brain Resilience researchers may help explain an enduring mystery about amyotrophic lateral sclerosis (ALS): why the disease kills off some of the brain and spinal cord's movement-controlling neurons while others show greater resilience.
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Developing a new methodology to identify biomarkers for male infertility
Researchers from the EHU-University of the Basque Country have developed a robust protocol to detect the molecules involved in the metabolic reactions of sperm. The new method enables a detailed analysis even with small samples and allows the detection of the largest number of po
Foto: Marta Branco / Pexels
Molecular machinery in cardiac mitochondria reacts to metabolic stress in unexpected way
In a recent study published in Nature Communications, researchers at Karolinska Institutet report that the molecular machinery responsible for cellular energy conversion is more interconnected than previously understood, shedding light on how mitochondria adapt under stress.
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Stress-linked gut viruses may help tumors evade the immune system
Chronic psychological stress can help tumors evade immune attack through a chain of molecular events involving gut bacteria and viruses within those bacteria, according to a study led by Weill Cornell Medicine investigators. The findings unveil a new layer of cancer biology, alon
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Small-molecule antiviral drug targets ACE2 receptor to block coronaviruses from entering c
The ongoing evolution of SARS-CoV-2, particularly the rapid emergence of the omicron variant and its sublineages, has weakened the effectiveness of existing vaccines and antiviral drugs, underscoring the potential risk of future coronavirus pandemics. In response, a joint researc
New Tfr cell model uncovers molecular switches that restrain antibody responses
New Tfr cell model uncovers molecular switches that restrain antibody responses
For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular regulatory T cells (Tfr cells) play a key role in this process by limiting excessive immune responses and helping to maintain immune tolerance. Researchers
Foto: Google DeepMind / Pexels
Nanotech platform combining paclitaxel with siRNA boosts immune response against lung canc
Researchers at the University of Arizona R. Ken Coit College of Pharmacy have developed a new strategy that helps the immune system recognize and attack lung cancer tumors more effectively. By packaging a chemotherapy drug and an RNA molecule in a tiny lipid carrier, the team boo
Researchers discover a cause of neuron excitability in ALS, suggesting a new potential tre
Researchers discover a cause of neuron excitability in ALS, suggesting a new potential tre
Digging deep into the molecular mechanisms behind ALS, researchers at the Les Turner ALS Center at Northwestern Medicine have discovered why nerve cells overfire in the disease. Not only that—they have also designed a new drug to stop this overfiring, which could potentially slow
Foto: Ivan S / Pexels
Thirty years later: A reappraisal of Alzheimer's disease risk in Japanese APOE-e4 homozygo
Researchers at Niigata University have conducted the first comprehensive reappraisal in nearly 30 years of the risk of Alzheimer's disease (AD) associated with APOE-e4 homozygosity (e4*4) in the Japanese population. Their findings, published in the journal Molecular Neurodegenera
Foto: Anna Tarazevich / Pexels
New therapeutic target for cancer identified by revealing how cancer 'hijacks' blueprint f
Anti-angiogenic therapies targeting VEGF have been widely used in cancer treatment, yet their long-term efficacy remains limited. Tumor vascular endothelial cells (TECs) exhibit high adaptive plasticity, enabling them to resist treatment and sustain tumor growth, but the molecula