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Epigenetic mapping provides deeper insight into leukemia
Researchers at Karolinska Institutet in Sweden and Kyoto University in Japan have identified new subgroups of the blood cancer acute myeloid leukemia. The study, published in the journal Nature, shows that changes in the regulation of genes within cells can help explain variation
New mechanism explains how nerve cells form one long output branch
New mechanism explains how nerve cells form one long output branch
DZNE researchers have uncovered a mechanism that determines why a neuron usually forms a single, long extension called an "axon"—a phenomenon that is fundamental to how our brain functions. Contrary to the common view that external cues drive axon formation, the team of scientist
Looks good, feels bad? New review explains why modern design can strain your brain
Modern, human-made environments that feature certain design elements can overload the brain, causing visual discomfort and stress, according to a new University of Stirling study. Visual discomfort refers to the unpleasant feelings or strain people experience when viewing certain
Brain-body connection: Expert shares tips to reduce risk of cognitive decline, Alzheimer's
The same lifestyle choices that reduce your risk of heart disease, diabetes and cancer can also reduce your risk of cognitive decline. Bryan Woodruff, M.D., a cognitive neurologist at Mayo Clinic in Arizona, explains the brain-body connection, lifestyle changes to foster brain he
Disordered collagen may help explain hip fractures beyond bone density, X-rays reveal
Fractures of the femoral neck are not simply due to insufficient bone density. Also significant is their nanostructure—the orientation of the collagen fibers that make up bones, according to research conducted by scientists at the Paul Scherrer Institute PSI using a new X-ray tec
New study provides first evidence of dopamine system injury in the brain of long COVID pat
New study provides first evidence of dopamine system injury in the brain of long COVID pat
A new brain imaging study led by researchers at the Center for Addiction and Mental Health (CAMH), published in eBioMedicine, provides the strongest evidence to date that long COVID is associated with injury to dopamine-releasing neurons in the brain—a finding that may explain sy
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Demystifying the molecular mechanisms of general anesthesia
Researchers at Weill Cornell Medicine and Birkbeck, University of London, have identified a site where a commonly used anesthetic binds to sodium ion channels, revealing a molecular mechanism that may explain how these drugs dampen communication between neurons. Ion channels are
Researchers reveal immune mechanisms that drive development of rare allergic stomach disea
Researchers reveal immune mechanisms that drive development of rare allergic stomach disea
Researchers at Tel Aviv University have developed one of the first experimental models that faithfully reproduces eosinophilic gastritis (EoG), a rare but increasingly recognized allergic disease of the stomach. Using this model, they identified the immune pathways responsible fo
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Signaling pathway may help predict immunotherapy response in glioblastoma
Northwestern Medicine scientists have uncovered a biological mechanism that helps explain why most patients with glioblastoma fail to respond to immunotherapy, according to their study published in Nature Communications.
Why some people are more prone to negative emotions than others
Why are some people particularly prone to anxiety, worry or stress, while others remain more composed? An international study led by the Central Institute of Mental Health (CIMH) shows that the amygdala—previously considered central to these processes—apparently does not explain
What's a 'sleep debt'? Can I ever pay it back? An expert explains
What's a 'sleep debt'? Can I ever pay it back? An expert explains
Maybe you're a new parent or someone who lies awake at night. If so, you may have started to worry you're not getting enough sleep.
Genetic safeguard protects the female heart—and what happens when it's lost
Men and women are not born with the same risk of heart disease, and for decades scientists have struggled to explain why. A new study from the University of North Carolina at Chapel Hill, published in Genes & Development, offers an answer: The female heart depends on a molecular