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Researchers at The University of Texas MD Anderson Cancer Center have created a comprehensive single-cell map of the tumor immune microenvironment in multiple myeloma and its precursor conditions. The study provided insights that may explain why patients with similar diagnoses of

A constant interplay takes place on the surface of the body between cells, the immune system and the skin microbiota. We do not notice it—until the balance is disturbed. Then it becomes clear that the outermost layer of the skin plays a crucial role in the well-being of the whole

Scientists from the University of Bath (UK) have shed new light on how Crohn's disease develops and why it affects people differently after finding new evidence of a link between a key immune system gene in the gut and signaling of the hormone estrogen.

Two new studies jointly published in Nature Communications reveal that certain species of fungi in the gut play a key role in the development of immune dysregulation and some pediatric allergic diseases—and may be promising targets for new therapies.

Researchers have identified a critical biological difference in how glioblastoma develops in male and female laboratory models, pinpointing an immune pathway that fuels tumor growth only in females. The study shows that the neurotransmitter GABA boosts the cancer-protecting activ

Systemic lupus erythematosus (SLE), the most common form of lupus, is an autoimmune disorder that occurs more frequently in women. Having multiple X chromosomes has been associated with an increased risk of developing lupus; however, the reason for this link is still not fully un

Researchers at Hospital for Special Surgery (HSS) have identified a specialized population of immune cells that plays a central role in driving abnormal tissue growth in rheumatoid arthritis (RA), offering new insight into disease progression and potential treatment strategies. T

In autoimmune disorders, immune cells targeting "self" proteins are mistakenly activated, resulting in abnormal expansion and responsiveness. These disorders are known to reduce patients' quality of life over a prolonged period. This can be attributed to CD4+ T cells, which play

The immune system depends on molecular alarms that detect danger inside cells. One of these alarms is STING, short for "stimulator of interferon genes." STING helps cells respond to infections, damaged DNA and cancer. When it activates at the right time, it helps protect the body

Researchers at Mayo Clinic have uncovered a previously hidden step in how the immune system prepares to fight cancer, a discovery that could help scientists develop more effective and longer-lasting cancer immunotherapies.

Chronic psychological stress can help tumors evade immune attack through a chain of molecular events involving gut bacteria and viruses within those bacteria, according to a study led by Weill Cornell Medicine investigators. The findings unveil a new layer of cancer biology, alon

For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular regulatory T cells (Tfr cells) play a key role in this process by limiting excessive immune responses and helping to maintain immune tolerance. Researchers