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Pancreatic cancer is one of the deadliest cancers and the third-leading cause of cancer-related death in the United States. While scientists continue searching for new therapies, advances can also come from understanding how existing drugs work. By uncovering the underlying biolo

Two new studies jointly published in Nature Communications reveal that certain species of fungi in the gut play a key role in the development of immune dysregulation and some pediatric allergic diseases—and may be promising targets for new therapies.

Researchers from the University of Kansas have shown a link between reproductive hormone exposure throughout life and brain health in 459 women ages 65 to 80. They discovered older women who had used hormonal birth control in young adulthood were more likely to have larger volume

A parasitic worm might be the impetus behind a new generation of medicine. In a recent review in published in Clinical & Translational Immunology, Neima Briggs, MD, Ph.D., instructor of medicine (infectious diseases) at Yale School of Medicine, found that certain types of parasit

As the leading cause of viral gastroenteritis worldwide, norovirus is an all too familiar ailment. Its telltale digestive upset—not to mention its reputation for being notoriously contagious—has earned it the nicknames "winter vomiting bug" and "stomach flu." Yet despite millions

Researchers at National Jewish Health have uncovered a previously unknown mechanism that helps drive inflammation in allergic asthma, offering new insight into how the disease develops and potentially revealing new targets for future therapies.

Anti-angiogenic therapies targeting VEGF have been widely used in cancer treatment, yet their long-term efficacy remains limited. Tumor vascular endothelial cells (TECs) exhibit high adaptive plasticity, enabling them to resist treatment and sustain tumor growth, but the molecula

Scientists at The Wistar Institute have shown that a single injection of a small, circular piece of genetic instruction can produce weight loss and blood glucose control in murine models that lasts up to 10 times as long as incretin-mimicking drugs like Ozempic and Wegovy. If sho

Research by the Barcelona Institute for Biomedical Research (IIBB), part of the Spanish National Research Council (CSIC), and the Institut de Recerca Sant Pau (IR Sant Pau) provides some of the first evidence that psychological therapies act as biological stimuli that induce mole

New findings from a trial conducted at Children's Hospital Colorado (Children's Colorado) and University of Colorado (CU) Anschutz School of Medicine demonstrate significantly increased growth rates in children with achondroplasia, the most common form of dwarfism. These results

A team of researchers at the University of Warwick and Monash University has solved a puzzle that has stumped drug developers for decades: how bacteria naturally create multiple versions of powerful cancer therapies. The breakthrough could accelerate the development of new treatm

Researchers at VIB and KU Leuven, with international partners, have uncovered how fatty liver disease can fuel the most aggressive form of metastatic colorectal cancer. The findings, which appear in the journal Nature, not only explain why some patients face dramatically poorer o