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Researchers at Trinity College Dublin have discovered that microglia—the main immune cells of the brain—play a critical role in maintaining the stability of neuronal networks in Alzheimer's disease. Crucially, this suggests treatments that indiscriminately suppress these cells co

Researchers have discovered that a microscopic skeleton inside neurons does much more than hold cells together. It acts as a gatekeeper that controls what brain cells absorb and when they absorb it. When this protective structure weakens, neurons rapidly take in harmful proteins

A new study from the Knight Initiative for Brain Resilience researchers may help explain an enduring mystery about amyotrophic lateral sclerosis (ALS): why the disease kills off some of the brain and spinal cord's movement-controlling neurons while others show greater resilience.

Markers of a new mechanism for cell death, called karyoptosis, have been found in the brains of patients with Alzheimer's disease and frontotemporal dementia (FTD).

Studies of genetics conducted in yeast cells, human neurons, mice or other model systems often reveal networks of genes that could contribute to complex diseases, such as breast cancer, type 2 diabetes and Parkinson's disease. But those findings don't always translate to human bi

Alzheimer's disease is driven by a buildup of a toxic protein called Tau that kills neurons. As toxic Tau spreads to new regions of the brain, symptoms worsen and ultimately become fatal.

The environment experienced by young zebrafish influences both the shape and electrical activity of the neurons in the eye, which affects subsequent behavior.

Digging deep into the molecular mechanisms behind ALS, researchers at the Les Turner ALS Center at Northwestern Medicine have discovered why nerve cells overfire in the disease. Not only that—they have also designed a new drug to stop this overfiring, which could potentially slow

Over the past decade, researchers at WashU Medicine have established that a molecule called SARM1 is a central trigger in the loss of axons, the vital wiring of the nervous system. Axon loss is characteristic of many neurodegenerative diseases, such as amyotrophic lateral scleros

University of Queensland researchers have developed a drug that activates a hard-to-target immune receptor—a breakthrough that could lead to new treatments for neurodegenerative conditions like motor neuron disease (MND).

A research team led by Prof. Hyosang Lee of the Department of Brain Sciences at DGIST has identified TWIK-1, a type of potassium channel expressed in the spinal cord and peripheral sensory neurons of the somatosensory system, as a key molecular regulator of touch sensation and ch

Autophagy is the process by which cells remove damaged proteins, recycle worn-out organelles (e.g., mitochondria), clear cellular waste and provide nutrients during stress. Autophagy is essential for muscles because they are constantly under mechanical stress. If autophagy is too