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165 notícias encontradas para "cells"
Skin renews despite 60% to 70% fibroblast depletion in mice, challenging long-held assumpt
Human skin is constantly rebuilding itself. Every few weeks, the outermost layers shed and are replaced by new cells pushed up from the base. For decades, scientists believed this renewal depended heavily on fibroblasts, a class of supportive cells nestled in the deeper layer of
Hidden mechanism driving joint tissue growth in rheumatoid arthritis has been found
Hidden mechanism driving joint tissue growth in rheumatoid arthritis has been found
Researchers at Hospital for Special Surgery (HSS) have identified a specialized population of immune cells that plays a central role in driving abnormal tissue growth in rheumatoid arthritis (RA), offering new insight into disease progression and potential treatment strategies. T
New technology helps reveal how the heart generates cells with regenerative potential
New technology helps reveal how the heart generates cells with regenerative potential
Two research teams at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have developed a pioneering technique in Spain to characterize the proteome of individual cardiomyocytes—the cells responsible for heart contraction.
Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases
Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases
In autoimmune disorders, immune cells targeting "self" proteins are mistakenly activated, resulting in abnormal expansion and responsiveness. These disorders are known to reduce patients' quality of life over a prolonged period. This can be attributed to CD4+ T cells, which play
Mapping the hidden rules of a key immune sensor
The immune system depends on molecular alarms that detect danger inside cells. One of these alarms is STING, short for "stimulator of interferon genes." STING helps cells respond to infections, damaged DNA and cancer. When it activates at the right time, it helps protect the body
Eliminating cancer cells that survive KRAS inhibition: A potential way to prevent relapse
Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory systems are disrupted, cells can acquire the ability to grow uncontrollably and become cancerous. One of the most important cancer-related signaling molecul
Hidden thymus step may prime cancer-killing T cells earlier than expected
Hidden thymus step may prime cancer-killing T cells earlier than expected
Researchers at Mayo Clinic have uncovered a previously hidden step in how the immune system prepares to fight cancer, a discovery that could help scientists develop more effective and longer-lasting cancer immunotherapies.
First 3D views of human cone opsins reveal how daylight vision reacts so fast
First 3D views of human cone opsins reveal how daylight vision reacts so fast
The retina of the human eye contains 6–7 million cone cells. These cells contain light-sensitive proteins known as cone opsins. They enable us to perceive our surroundings in detail in daylight. They allow us to see the world in thousands of colors: red strawberries, green leaves
Special protein in the brain's cleansing system may contribute to loss of brain function i
Alzheimer's disease is a progressive and permanent loss of nerve cells in the brain. The breakdown causes memory loss, functional impairment and personality changes. In a new study published in Nature Aging, researchers found that the age-related reduction in a specific protein m
Small-molecule antiviral drug targets ACE2 receptor to block coronaviruses from entering c
The ongoing evolution of SARS-CoV-2, particularly the rapid emergence of the omicron variant and its sublineages, has weakened the effectiveness of existing vaccines and antiviral drugs, underscoring the potential risk of future coronavirus pandemics. In response, a joint researc
New Tfr cell model uncovers molecular switches that restrain antibody responses
New Tfr cell model uncovers molecular switches that restrain antibody responses
For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular regulatory T cells (Tfr cells) play a key role in this process by limiting excessive immune responses and helping to maintain immune tolerance. Researchers
Opposing protein pathways steer skin stem cells toward renewal or repair
Two proteins with opposing functions orchestrate the development and maintenance of healthy skin, Stanford Medicine researchers have found. Modulating their activity with topical drugs could reduce inflammation, aid wound healing and slow or halt the growth of skin cancer, the re