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165 notícias encontradas para "cells"
Intravesical CAR T therapy opens door to bladder-sparing cancer treatment
Researchers at Weill Cornell Medicine, Cedars-Sinai Medical Center and Roswell Park Comprehensive Cancer Center have developed genetically engineered CAR T cells that specifically target and kill bladder cancer cells. The study, published in the Journal of Experimental Medicine (
New tool helps uncover rare genetic mutations in common diseases, including Parkinson's
Studies of genetics conducted in yeast cells, human neurons, mice or other model systems often reveal networks of genes that could contribute to complex diseases, such as breast cancer, type 2 diabetes and Parkinson's disease. But those findings don't always translate to human bi
Blood vessel cells keep fixed signaling roles for weeks, reshaping view of capillary commu
Blood vessel cells keep fixed signaling roles for weeks, reshaping view of capillary commu
The cells lining skin capillaries are constantly sending each other messages—tiny pulses of calcium that help regulate blood flow, sense physical forces and keep vessel walls intact. Scientists have known about this signaling for decades. What they didn't know, until now, is that
Intracellular mechanisms promote tumor survival during hypoxia
Northwestern Medicine scientists have, for the first time, described the underlying mechanisms that regulate how cells rapidly change gene expression in response to hypoxia, a key feature of many treatment-resistant tumors, according to a recent study published in Science Advance
Researchers discover a cause of neuron excitability in ALS, suggesting a new potential tre
Researchers discover a cause of neuron excitability in ALS, suggesting a new potential tre
Digging deep into the molecular mechanisms behind ALS, researchers at the Les Turner ALS Center at Northwestern Medicine have discovered why nerve cells overfire in the disease. Not only that—they have also designed a new drug to stop this overfiring, which could potentially slow
Scientists uncover how ovarian cancer resists chemotherapy—and how to reverse it
Scientists uncover how ovarian cancer resists chemotherapy—and how to reverse it
Michigan State University researchers have identified how ovarian cancer cells become resistant to chemotherapy and discovered a protein that, when blocked, can restore the drug's effectiveness.
New therapeutic target for cancer identified by revealing how cancer 'hijacks' blueprint f
Anti-angiogenic therapies targeting VEGF have been widely used in cancer treatment, yet their long-term efficacy remains limited. Tumor vascular endothelial cells (TECs) exhibit high adaptive plasticity, enabling them to resist treatment and sustain tumor growth, but the molecula
Study reveals how early-life cellular process helps shape lifelong immune health
Study reveals how early-life cellular process helps shape lifelong immune health
Researchers at Hospital for Special Surgery (HSS) have uncovered a critical link between the immune system in early life and its function in adulthood. The study, published in Science Immunology, identifies a new role for specialized skin immune cells, called Langerhans cells, in
Study reveals how leukemia cells enter and damage lungs
Study reveals how leukemia cells enter and damage lungs
Led by NYU Langone Health researchers, a new study shows how blood cancer cells enter the lungs, damage tissue and cause severe breathing problems.
Antibiotics reverse damage caused to blood stem cells by chronic Salmonella, study suggest
A new study from Ben-Gurion University of the Negev (BGU) has revealed that long-term Salmonella infections severely damage blood stem cells—the essential factory cells in bone marrow that produce all the body's blood and immune cells. However, the research, published in Cell Rep
Cancer cell 'degraders' target two proteins at once to defeat treatment resistance
Cancer cell 'degraders' target two proteins at once to defeat treatment resistance
Researchers from two Technion faculties have jointly developed a new compound and demonstrated its effectiveness against aggressive tumor cells.
Kidney cancer gene reveals an unexpected weakness and a new path for treatment
A common genetic mutation that helps some kidney cancers survive may also expose an unexpected weakness, one that MUSC Hollings Cancer Center researchers hope to transform into a new treatment strategy. In a study published in Cancer Research, Aguirre de Cubas, Ph.D., and colleag