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For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular regulatory T cells (Tfr cells) play a key role in this process by limiting excessive immune responses and helping to maintain immune tolerance. Researchers

A new study has uncovered a key mechanism that helps one of the deadliest brain cancers evade the immune system, according to the study published in The Journal of Clinical Investigation.

Researchers at National Jewish Health have uncovered a previously unknown mechanism that helps drive inflammation in allergic asthma, offering new insight into how the disease develops and potentially revealing new targets for future therapies.

Studies of genetics conducted in yeast cells, human neurons, mice or other model systems often reveal networks of genes that could contribute to complex diseases, such as breast cancer, type 2 diabetes and Parkinson's disease. But those findings don't always translate to human bi

A research team led by Prof. Wang Hongzhi at the Hefei Institutes of Physical Science, Chinese Academy of Sciences, has found a novel role of prostaglandin E synthase 3 (PTGES3) in liver cancer, revealing how it drives both tumor growth and immune suppression.

Major depressive disorder (MDD) is a psychiatric condition characterized by persistent feelings of sadness, a loss of interest in everyday activities, altered sleeping and/or eating patterns, low energy, and difficulty concentrating on tasks. While it is one of the most widesprea

Michigan State University researchers have identified how ovarian cancer cells become resistant to chemotherapy and discovered a protein that, when blocked, can restore the drug's effectiveness.

Researchers at Hospital for Special Surgery (HSS) have uncovered a critical link between the immune system in early life and its function in adulthood. The study, published in Science Immunology, identifies a new role for specialized skin immune cells, called Langerhans cells, in

Few areas of the body face more daily stress and potential damage than the stomach, which must manage everything we swallow. Along with this constant strain, the stomach also produces acid that can damage its own lining and increase the risk of ulcers.

Researchers at Umeå University show that the protein METTL3 helps breast cancer cells spread. By regulating the release of molecules, METTL3 makes it easier for tumors to invade surrounding tissue and form metastases. The discovery reveals a previously unknown function of METTL3

Researchers at the University of Kentucky Sanders-Brown Center on Aging have uncovered evidence that a single genetic variant may influence the risk of two of the diseases people fear most—dementia and cancer—but in opposite ways.

An artificial intelligence model capable of reading and interpreting animal behavior like language has been developed by researchers at KAIST. The team created an AI model that learns behavioral data in a manner similar to natural language and was able to independently identify s