Cancer cell 'degraders' target two proteins at once to defeat treatment resistance
Researchers from two Technion faculties have jointly developed a new compound and demonstrated its effectiveness against aggressive tumor cells.
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Kidney cancer gene reveals an unexpected weakness and a new path for treatment
A common genetic mutation that helps some kidney cancers survive may also expose an unexpected weakness, one that MUSC Hollings Cancer Center researchers hope to transform into a new treatment strategy. In a study published in Cancer Research, Aguirre de Cubas, Ph.D., and colleag
Chain reaction in cells may be driving low energy in ME/CFS patients
Griffith University researchers have identified a key immune cell dysfunction in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), offering new clues about the condition.
Two studies point to beta cells as active players in type 1 diabetes
Type 1 diabetes is widely understood as an autoimmune disease, with the immune system attacking the insulin-producing beta cells of the pancreas. But two new studies suggest those cells may be more than passive victims. Together, the findings indicate that beta cells' own stress
Uncovering gene-based clues to how disrupted healing in stomach cells increases cancer ris
Few areas of the body face more daily stress and potential damage than the stomach, which must manage everything we swallow. Along with this constant strain, the stomach also produces acid that can damage its own lining and increase the risk of ulcers.
New mechanism behind breast cancer metastasis uncovered
Researchers at Umeå University show that the protein METTL3 helps breast cancer cells spread. By regulating the release of molecules, METTL3 makes it easier for tumors to invade surrounding tissue and form metastases. The discovery reveals a previously unknown function of METTL3
Repurposed epilepsy drug could be used to boost vaccine protection among elderly
A drug commonly used to treat epilepsy could be repurposed to significantly boost the response to vaccines in humans, helping protect those for whom the vaccine is less effective, such as older adults or immunocompromised people. A Cambridge-led team showed that the drug more tha
CAR T cell therapy targets key mutation driving rare blood cancers
A new form of CAR T-cell therapy has been designed to find and destroy the cancer-driving stem cells responsible for a group of blood cancers known as myeloproliferative neoplasms (MPNs), while leaving healthy blood cells unharmed, according to new research led by UCL and Univers
Discovery could help prevent cancer drug resistance before it starts
Cancer cells are quick to develop resistance to anti-tumor drugs. New research by scientists from the University of California, Davis, shows how cancers adapt to evade a class of anti-tumor drugs called BET inhibitors and offers hope for more effective therapies.
Cancer also knows how to wait: Study uncovers the hidden step between mutation and tumor b
The development of cancer is not a process triggered immediately by the emergence of an oncogenic mutation. There is growing evidence for the existence of an intermediate phase—hitherto poorly defined—in which mutated cells remain in a latent state, "accumulating the potential ne
Dementia-causing substance turns into a therapeutic 'switch' with new Alzheimer's drug str
A substance that worsens dementia has become a "switch" that initiates treatment. KAIST researchers have developed a new therapeutic approach that uses hydrogen peroxide (H₂O₂), a reactive oxygen species that damages cells and increases in the brains of patients with Alzheimer's
Tumors hijack macrophages after they clear dead cells, real-time tracking reveals
Researchers at Tel Aviv University's Gray Faculty of Medical and Health Sciences have uncovered how a natural and essential immune system process can be hijacked to promote cancer progression. In a new study, the research team developed an advanced technology that enabled it to t