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1,431 notícias encontradas para "target"
Radioligand therapy significantly prolongs progression-free survival in metastatic GEP-NET
Results of the Phase III COMPETE clinical trial show that the targeted radiotherapeutic agent [177Lu]Lu-edotreotide significantly prolonged progression-free survival in patients with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) compared with targeted therapy
Foto: Anna Tarazevich / Pexels
Tumor on a chip reveals how pancreatic cancer hijacks immune cells in real time
A new "tumor-on-a-chip" model is giving scientists a live look at how pancreatic cancer can recruit the body's own immune cells to help tumors survive. Researchers say the findings, published in Biofabrication, reveal possible new targets to weaken the cancer's defenses and make
New approach could expand CAR T therapy from blood cancers to solid tumors
New approach could expand CAR T therapy from blood cancers to solid tumors
Researchers at the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute report that combining CAR T cell immunotherapy with a targeted radiopharmaceutical significantly improved tumor regression in preclinical models of neuroblastoma, a rare and
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Key gut protein balances immune protection and tolerance
A protein produced by gut immune cells orchestrates both immune protection against pathogens and immune tolerance of gut bacteria, according to a study led by Weill Cornell Medicine investigators. The discovery illuminates the complex biology of the gut immune system and could le
Clinical trial offers strong evidence that nerve blocks can cut opioid use after cardiac s
A clinical trial led by St. Michael's Hospital researchers found that using nerve blocks, an anesthesia technique to numb targeted areas of the body, significantly reduced opioid use after cardiac surgery—findings the authors say could reshape how the potentially addictive drugs
Foto: Tara Winstead / Pexels
New drug against metastatic prostate cancer made entirely from human proteins
A new cancer drug may be able to inhibit both tumor growth and the spread of aggressive prostate cancer. This is shown in a study conducted by researchers at Umeå University together with international collaborators, published in the journal Signal Transduction and Targeted Thera
Investigational drug that targets DNA damage help could treat Alzheimer's disease
Accumulation of DNA damage in the brain's neurons may contribute to the development of Alzheimer's disease. New research in FEBS Open Bio demonstrates the therapeutic potential of a drug that targets this process.
Foto: Mahendra Jagadeesh / Pexels
Gut bacteria boost immune system, help send vitamin A to T cells
Scientists at UT Southwestern Medical Center have discovered that gut bacteria help regulate the development of the body's immune system by directing the movement of vitamin A through a previously unrecognized cellular network. The preclinical findings, published in Cell Host & M
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Targeted phages curb Crohn's-linked gut inflammation by disabling harmful E. coli traits
A research team at McMaster University has developed a targeted approach to treating inflammatory bowel disease (IBD) using bacteriophages, viruses that infect specific bacteria, to disarm harmful microbes without disrupting the broader gut ecosystem.
AI-guided CRISPR uncovers oxytocin receptor as unexpected psoriasis drug target
Biohub researchers have performed what they believe is the first genome-wide CRISPR study of primary human adult skin cells, then used an AI model to mine the results for overlooked drug targets for psoriasis. They found an unlikely candidate: the receptor for oxytocin, a hormone
How random sounds played while sleeping impair memory formation
How random sounds played while sleeping impair memory formation
For several years now, sleep research has been focusing intensively on the question of whether targeted auditory stimulation during sleep can improve the consolidation of new memories. A research team in Freiburg led by the neuropsychologists Prof. Dr. Monika Schönauer and Dr. No
Glycoprotein G unlocks genital herpes spread to nerves, revealing vaccine target
Researchers at the University of Gothenburg have identified a key protein that allows the virus that causes genital herpes to get into the nervous system. The discovery, made in experiments on mice, could pave the way for future vaccines against the disease. The study is publishe