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292 notícias encontradas para "cell"
Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases
Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases
In autoimmune disorders, immune cells targeting "self" proteins are mistakenly activated, resulting in abnormal expansion and responsiveness. These disorders are known to reduce patients' quality of life over a prolonged period. This can be attributed to CD4+ T cells, which play
Foto: Jakub Zerdzicki / Pexels
Mapping the hidden rules of a key immune sensor
The immune system depends on molecular alarms that detect danger inside cells. One of these alarms is STING, short for "stimulator of interferon genes." STING helps cells respond to infections, damaged DNA and cancer. When it activates at the right time, it helps protect the body
CAR T cell therapy leads to 10-year remissions in B-cell lymphoma patients
CAR T cell therapy leads to 10-year remissions in B-cell lymphoma patients
After a median follow-up of 10 years, more than one-third of patients with large B-cell lymphoma and nearly half of patients with follicular lymphoma who received a single infusion of tisagenlecleucel—the CAR T-cell therapy developed by Carl June, MD, that would go on to become t
Foto: Darina Belonogova / Pexels
Eliminating cancer cells that survive KRAS inhibition: A potential way to prevent relapse
Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory systems are disrupted, cells can acquire the ability to grow uncontrollably and become cancerous. One of the most important cancer-related signaling molecul
Foto: Paul Seling / Pexels
Video of tiny vessels in the eye assessed by AI may replace needle sticks for anemia scree
A new collaborative study by Tel Aviv University and Sheba Medical Center marks a significant advance toward noninvasive blood testing, one of the most significant unmet needs in the market. The researchers have developed an artificial intelligence–based system capable of assessi
Vulnerable ALS neurons reveal molecular warning signs before cell death begins
A new study from the Knight Initiative for Brain Resilience researchers may help explain an enduring mystery about amyotrophic lateral sclerosis (ALS): why the disease kills off some of the brain and spinal cord's movement-controlling neurons while others show greater resilience.
Foto: Merlin Lightpainting / Pexels
AI framework helps identify new targets for CAR T cell therapy
Leading CAR T cell therapy researchers have developed a human-in-the-loop artificial intelligence (AI) framework that centers scientists' expertise to find viable target antigens for CAR T cell therapy. The work was led by experts from the Perelman School of Medicine at the Unive
Hidden thymus step may prime cancer-killing T cells earlier than expected
Hidden thymus step may prime cancer-killing T cells earlier than expected
Researchers at Mayo Clinic have uncovered a previously hidden step in how the immune system prepares to fight cancer, a discovery that could help scientists develop more effective and longer-lasting cancer immunotherapies.
Foto: Marta Branco / Pexels
Molecular machinery in cardiac mitochondria reacts to metabolic stress in unexpected way
In a recent study published in Nature Communications, researchers at Karolinska Institutet report that the molecular machinery responsible for cellular energy conversion is more interconnected than previously understood, shedding light on how mitochondria adapt under stress.
New mechanism found for neuronal death in Alzheimer's and frontotemporal dementia
New mechanism found for neuronal death in Alzheimer's and frontotemporal dementia
Markers of a new mechanism for cell death, called karyoptosis, have been found in the brains of patients with Alzheimer's disease and frontotemporal dementia (FTD).
First 3D views of human cone opsins reveal how daylight vision reacts so fast
First 3D views of human cone opsins reveal how daylight vision reacts so fast
The retina of the human eye contains 6–7 million cone cells. These cells contain light-sensitive proteins known as cone opsins. They enable us to perceive our surroundings in detail in daylight. They allow us to see the world in thousands of colors: red strawberries, green leaves
Special protein in the brain's cleansing system may contribute to loss of brain function i
Alzheimer's disease is a progressive and permanent loss of nerve cells in the brain. The breakdown causes memory loss, functional impairment and personality changes. In a new study published in Nature Aging, researchers found that the age-related reduction in a specific protein m